Hair loss remedies exterior of the USA could embody merchandise made with cyproterone acetate offered below the model names Dianette, Androcur, Andro-Diane, Cyprone, and Cyprostat. Cyproterone acetate is a hormone-based remedy generally known as an antiandrogen that reduces testosterone within the physique, and it isn’t accepted to be used in the USA.
Cyproterone acetate is used elsewhere to manage the consequences of testosterone. In males, it’s used to deal with hypersexuality and handle an overactive sex drive, and to assist handle prostate cancer symptoms. In girls, it’s prescribed for therapy of extra physique hair or scalp hair loss resulting from excessive ranges of male hormones. Mixed with a second kind of hormone, ethinyl estradiol, cyproterone acetate comes as a mix form of birth control capsule prescribed to girls. These contraceptives are generally known as Diane 35, Diane 50, or Dianette. Cyproterone acetate additionally has been used as therapy for early puberty and extreme pimples.
“Cyproterone acetate and its derivatives work in female pattern hair loss by blocking male hormone response on hair follicles,” says dermatologist Amy McMichael, professor of dermatology at Wake Forest College Baptist Medical Heart in Winston Salem, N.C.
Cyproterone reduces the impact of testosterone on these hair follicles, stopping the hair loss that is because of testosterone hormone imbalances in girls. “The male hormones trigger miniaturization of the follicles, inflicting smaller and smaller hair on the highest of the scalp. As soon as this motion is blocked, the hairs don’t turn into miniaturized and contribute extra to [hair] density,” Dr. McMichael says.
Nevertheless, not one of the types of cyproterone acetate can be found as a prescription hair loss therapy in the USA.
Dangers Related to Cyproterone
Cyproterone acetate was first marketed within the Nineteen Seventies. Regardless of the long-running enchantment of those medicines to manage pimples, hair loss, and copy, these merchandise haven’t been with out controversy.
One of many more moderen controversies concerned the elevated danger of blood clots for girls taking these contraceptives. Within the early 2000s, Diane 35 was marketed as an acne-fighting remedy and as an oral contraceptive for girls. Nevertheless, there may be some proof that blood clots have been extra seemingly amongst girls taking cyproterone acetate with ethinyl estradiol. (Blood clots are a possible danger issue for a lot of girls taking oral contraceptives.) After this proof got here to mild, many nations, reminiscent of Canada, required a warning to be connected to the product.
Different potential dangers of utilizing cyproterone acetate-containing merchandise embody:
- Injury to the liver
- Despair or different temper modifications
- Osteoporosis (provided that used for a really very long time, as a result of potential impact on estrogen)
- In males, enlarged breasts and erectile dysfunction
- In males, decreased sperm rely
Sure folks shouldn’t use medicines that comprise cyproterone, together with people with liver disease, alcoholics, and other people with insulin-dependent diabetes.
Cyproterone in the USA?
These merchandise aren’t prone to be obtainable for prescription use towards hair loss in the USA anytime quickly.
“Getting Meals and Drug Administration approval is extraordinarily costly, and no pharmaceutical firm is keen to pay for the main research which are obligatory for submission of a drug approval,” says McMichael. Cyproterone acetate is at present below analysis in medical trials for the treatment of prostate cancer due to its potential means to restrict the impact of testosterone on the physique’s tissues.
Though it might be tempting to get these medicines abroad, keep in mind that it’s important to hold utilizing them to keep up the advantage of stopping hair loss. Due to the dangers concerned in taking cyproterone acetate, it’s best to seek the advice of a physician who is aware of your medical historical past earlier than you’re taking this remedy.