Votrient could cause gentle or severe unwanted effects. The next lists comprise a few of the key unwanted effects that will happen whereas taking Votrient. These lists don’t embrace all potential unwanted effects.
For extra details about the potential unwanted effects of Votrient, discuss along with your physician or pharmacist. They may give you recommendations on the way to cope with any unwanted effects that could be regarding.
Observe: The Meals and Drug Administration (FDA) tracks unwanted effects of medication it has permitted. If you need to inform the FDA a couple of aspect impact you’ve had with Votrient, you are able to do so via MedWatch.
Gentle unwanted effects
Gentle unwanted effects* which were reported with Votrient use embrace:
Most of those unwanted effects might go away inside just a few days or a few weeks. But when they develop into extra extreme or don’t go away, discuss along with your physician or pharmacist.
* This can be a partial record of gentle unwanted effects from Votrient. To find out about different gentle unwanted effects, discuss along with your physician or pharmacist, or view Votrient’s prescribing information.
† For extra details about this aspect impact, see “Facet impact particulars” beneath.
Severe unwanted effects
Severe unwanted effects from Votrient aren’t widespread, however they will happen. Name your physician instantly when you’ve got severe unwanted effects. Name 911 or your native emergency quantity in case your signs really feel life threatening or should you assume you’re having a medical emergency.
Severe unwanted effects and their signs which were reported with Votrient use embrace:
- Bleeding issues. Signs can embrace:
- bruising extra simply than common
- bleeding, resembling nosebleeds, bleeding gums, or bleeding that gained’t cease
- blood in your urine, which can look pink or brown
- Coronary heart issues, resembling slow heart rate, lengthy QT syndrome (a kind of abnormal heart rhythm), or heart failure. Signs differ by situation and might embrace:
- a fluttering feeling in your chest
- Blood clot in an artery, which can trigger a heart attack or stroke. Signs differ by location of the blood clot and might embrace:
- chest ache that will unfold to your arm, again, neck, or jaw
- numbness or weak point on one aspect of your physique, particularly your face or arm
- Blood clot in a vein, which can trigger deep vein thrombosis or pulmonary embolism. Signs differ by location of the blood clot and might embrace:
- ache, pores and skin discoloration, or swelling in a leg or arm
- sudden shortness of breath
- Thrombotic microangiopathy (blood clots in small blood vessels, which may injury organs such because the kidneys or mind). Signs differ by location of the blood clots and might embrace:
- bruising or bleeding extra simply than common
- urinating lower than common
- Gastrointestinal perforation (tear in your abdomen or intestines) or fistula (irregular connection between two elements of your intestines). Signs can embrace:
- ache or swelling in your stomach
- Lung issues, resembling interstitial lung disease or pneumonitis (each of which may trigger inflammation or scarring in your lungs). Signs can embrace:
- Posterior reversible encephalopathy syndrome, which causes swelling in your mind. Signs can embrace:
- bother pondering or talking
- adjustments in imaginative and prescient, together with lack of imaginative and prescient
- Hypothyroidism (underactive thyroid). Signs can embrace:
- Tumor lysis syndrome (a situation that may happen when quickly dying most cancers cells launch dangerous chemical compounds into your blood). Signs can embrace:
- urinating lower than common
- Infections. Signs can embrace:
- purple or swollen cuts or wounds
- Protein in your urine, which may be an early signal of kidney issues.
- Allergic reaction.*
- High blood pressure.*
- Liver injury.*†
* For extra details about this aspect impact, see “Facet impact particulars” beneath.
† Votrient has a
Facet impact particulars
Right here’s some element on sure unwanted effects this drug might trigger.
Some individuals might have high blood pressure whereas taking Votrient. This was probably the most widespread unwanted effects of Votrient seen in scientific research. Hypertension will increase the chance of heart failure, heart attack, and stroke. To learn the way usually hypertension occurred in scientific research, see Votrient’s prescribing information.
Your physician will verify your blood stress earlier than you begin Votrient therapy to verify the drug is protected so that you can take. If in case you have hypertension, you’ll doubtless must take medicine to regulate it earlier than you can begin taking Votrient. Hypertension doesn’t normally trigger signs. So your physician will monitor your blood stress whilst you’re taking Votrient to verify it’s nonetheless beneath management.
If in case you have hypertension whereas taking Votrient, your physician might scale back your dosage or have you ever cease therapy for some time. They could additionally prescribe medication to assist management your blood stress. But when your blood stress doesn’t enhance or could be very excessive, chances are you’ll must cease taking Votrient completely.
On uncommon events, Votrient could cause a sudden, extreme improve in blood stress referred to as a hypertensive crisis. This situation may be life threatening.
Signs of a hypertensive disaster can embrace:
If in case you have these signs whereas taking Votrient, name your physician instantly. Name 911 or your native emergency quantity in case your signs really feel life threatening or should you assume you’re having a medical emergency.
Votrient can typically trigger liver injury that may lead, in uncommon circumstances, to extreme or deadly liver issues, resembling liver failure.* It’s possible you’ll be extra prone to have liver injury with Votrient should you’re older than age 65 years.
Liver injury may be noticed early with blood exams referred to as liver function tests. These measure the degrees of liver enzymes in your blood. Liver enzymes are proteins that assist your liver perform its common capabilities. If blood exams present you will have elevated liver enzymes, which means cells in your liver are broken.
In scientific research, raised liver enzymes generally occurred in individuals taking Votrient. However extreme liver injury, liver failure, and demise have been uncommon. To learn the way usually these unwanted effects occurred in scientific research, see Votrient’s prescribing information.
Your physician will verify your liver perform earlier than you begin Votrient to verify the drug is protected so that you can take. You’ll even have frequent blood exams to verify your liver whilst you’re taking Votrient.
Though liver issues are normally detected in blood exams, they will typically trigger signs as properly. See your physician instantly when you’ve got any signs of liver issues whereas taking Votrient. These might embrace:
- nausea and vomiting
- ache within the higher proper a part of your stomach
- bruising extra simply than common
- dark-colored urine
- jaundice (yellowing of your pores and skin or the whites of your eyes)
- lack of urge for food
If in case you have liver issues whereas taking Votrient, your physician might lower your dosage or ask you to cease therapy for some time. This may permit your liver to recuperate. But when your liver doesn’t enhance, or when you’ve got extreme liver issues, chances are you’ll must cease Votrient completely.
* Votrient has a
Shade adjustments of your pores and skin and hair
You could have adjustments within the coloration of your hair or pores and skin whereas taking Votrient. These adjustments usually imply your pores and skin or hair loses pigmentation and turns into lighter in coloration. Your hair might develop into white.
Pores and skin and hair coloration adjustments have been among the many commonest unwanted effects reported with Votrient in scientific research. To learn the way usually these unwanted effects occurred in scientific research, see the drug’s prescribing information.
Pores and skin and hair coloration adjustments with Votrient aren’t dangerous. However should you discover them bothersome, discuss along with your physician. They are able to suggest methods to assist handle these unwanted effects. For instance, you might be able to use pure hair dyes to paint hair that’s turned white.
As with most medication, some individuals can have an allergic response after taking Votrient. Signs of a gentle allergic response can embrace:
- flushing (heat or redness/deepening of pores and skin coloration for a quick time)
A extra extreme allergic response is uncommon however potential. Signs of a extreme allergic response can embrace:
- swelling beneath your pores and skin, usually in your eyelids, lips, palms, or ft
- swelling of your tongue, mouth, or throat
- bother respiration
Name your physician instantly when you’ve got an allergic response to Votrient, because the response may develop into extreme. Name 911 or your native emergency quantity in case your signs really feel life threatening or should you assume you’re having a medical emergency.