- The most typical unwanted side effects seen with the J&J COVID-19 vaccine are ache on the injection web site, headache, and flu-like signs.
- There have been fewer circumstances of allergic reactions to the J&J vaccine in contrast with the Moderna-NIAID and Pfizer-BioNTech vaccines.
- The FDA will proceed to watch the security of the J&J vaccine because it’s rolled out to the American public.
All knowledge and statistics are based mostly on publicly accessible knowledge on the time of publication. Some info could also be outdated.
In February 2021, the Meals and Drug Administration (FDA) issued an emergency approval for the one-dose COVID-19 vaccine developed by Johnson & Johnson’s subsidiary firm Janssen Biotech.
As with the 2 mRNA vaccines authorized in December, the J&J vaccine has largely gentle unwanted side effects that may be managed with relaxation or an over-the-counter ache reliever.
To date, there have been fewer circumstances of allergic reactions to the J&J vaccine in contrast with the Moderna-NIAID and Pfizer-BioNTech vaccines, though J&J reported in February that two medical trial contributors had a extreme allergic response after receiving its vaccine.
The FDA will proceed to watch the security of the J&J vaccine because it’s rolled out to the American public.
Earlier than the FDA issued the Emergency Use Authorization (EUA) for the J&J COVID-19 vaccine, scientists from the company reviewed
Dr. Bruce Y. Lee, government director of Public Well being Computational and Operations Analysis and professor of well being coverage and administration at CUNY Graduate College of Public Well being and Well being Coverage, says the unwanted side effects seen in these trials fall into two essential classes.
“First are the injection web site reactions. That’s often ache, redness of the pores and skin ,or swelling on the injection web site,” he mentioned.
“After which there are systemic unwanted side effects — flu-like signs resembling fatigue, muscle aches, nausea, and probably fever.”
Information from the medical trials confirmed that round half of the individuals who obtained the vaccine had a neighborhood response. Ache on the injection web site was probably the most generally reported one, occurring in virtually all circumstances.
Native unwanted side effects started on common 2 days after vaccination. Ache and redness lasted for two days on common and swelling for 3 days on common.
The onset and length of native unwanted side effects diverse, however lower than 3 % of individuals had unwanted side effects that lasted longer than 7 days.
Extreme native unwanted side effects have been unusual, with lower than 1 % of individuals having extreme ache. A small variety of folks had reddening of the pores and skin close to the injection web site or swelling.
All of those native unwanted side effects have been reported extra usually amongst folks 18 to 59 years of age in comparison with these 60 years of age or older.
Systemic unwanted side effects occurred in about 55 % of people that obtained the vaccine.
Essentially the most generally reported ones have been headache, fatigue, and muscle ache, and in smaller numbers of individuals, nausea and fever.
These started on common 2 days after vaccination. Fatigue, headache, and muscle ache lasted on common 2 days. Nausea and fever lasted on common 1 day.
The onset and length of systemic unwanted side effects diverse, though fewer than 2 % of individuals skilled systemic unwanted side effects lasting longer than 7 days.
Lower than 2 % of the systemic unwanted side effects have been extreme, with the commonest being fatigue, muscle ache, and fever.
All the systemic unwanted side effects have been reported extra ceaselessly amongst youthful adults in comparison with older adults. The one exception was nausea, which occurred at about the identical fee in each teams.
Round one-fifth of individuals reported utilizing a drugs to alleviate their ache or fever inside 1 week of their vaccination. This was extra frequent amongst youthful adults.
Whereas it may be troublesome to match the efficacy of vaccines examined in several medical trials underneath completely different circumstances, Katelyn Jetelina, PhD, an assistant professor at College of Texas Well being College of Public Well being in Dallas, says unwanted side effects are simpler to match.
“As a result of the medical trials have been giant and randomized,” she mentioned, “we’re assured that these unwanted side effects aren’t as a consequence of particular person variation, however reasonably nearer to the ‘true’ expertise for vaccinated adults.”
The kind of unwanted side effects seen with the J&J vaccine are in keeping with these skilled by individuals who obtained one of many mRNA vaccines.
Nevertheless, “within the medical trials [for the J&J vaccine], fewer folks reported unwanted side effects, relative to Pfizer or Moderna, particularly if we examine J&J to the second dose of Pfizer or Moderna,” Jetelina mentioned.
Over 80 % of people that obtained the
For the Moderna-NIAID vaccine, about 55 % of individuals skilled systemic reactions after the primary dose — just like the J&J vaccine — however 80 % skilled them after the second dose.
The Pfizer-BioNTech vaccine additionally had the next fee of systemic reactions than the J&J vaccine, particularly after the second dose.
Lee says the stronger unwanted side effects after the second dose of the mRNA vaccines is “in all probability as a result of your immune system is primed from receiving the primary dose.”
Medical trials present necessary details about the security of vaccines, however the federal authorities continues to watch vaccines after they’re authorized.
This contains monitoring vaccines by means of the
“Any time you might have an opposed occasion from a vaccine, it’s necessary to report it,” mentioned Lee, “as a result of we actually wish to see how the vaccine behaves in a broader inhabitants and over time.”