Client Medication Info (CMI)
This leaflet gives vital details about utilizing EFERAS. You also needs to communicate to your physician or pharmacist if you need additional data
or when you’ve got any considerations or questions on utilizing EFERAS.
The place to search out data on this leaflet:
Why am I utilizing EFERAS?
EFERAS comprises the energetic ingredient deferasirox. EFERAS is used to deal with a situation referred to as iron overload, which occurs when the
physique has an excessive amount of iron. This could happen after repeated blood transfusions.
The physique has no pure approach to take away extra iron which comes with blood transfusions.
EFERAS can be used to deal with sufferers who’ve iron overload related to their
thalassemia syndromes, however who are usually not transfusion dependent. In sufferers with non-transfusion-dependent-thalassemia
syndromes, iron overload might develop over time as a consequence of elevated absorption of dietary
iron in response to low cell counts.
Over time, this extra iron can injury vital organs such because the liver and coronary heart.
What ought to I do know earlier than I take advantage of EFERAS?
Don’t use EFERAS if:
you’re allergic to deferasirox, or any of the elements listed on the finish of this
All the time examine the elements to ensure you should use this medication.
Verify together with your physician should you:
have another medical circumstances reminiscent of kidney or liver issues
have low platelet or white blood cell counts
have a complicated stage of myelodysplastic syndrome (MDS) or superior most cancers
take any medicines for another situation
you perceive these dangers and how you can monitor for them. See further data
below Part 6. Are there any side effects?
Being pregnant and breastfeeding
Verify together with your physician in case you are pregnant or intend to turn out to be pregnant.
Speak to your physician in case you are breastfeeding or intend to breastfeed.
What if I’m taking different medicines?
Inform your physician or pharmacist in case you are taking another medicines, together with any
medicines, nutritional vitamins or dietary supplements that you simply purchase and not using a prescription out of your pharmacy,
grocery store or well being meals store.
ciclosporin, used to stop organ rejection following transplantation or to deal with
rheumatoid arthritis or atopic dermatitis
midazolam, a drugs used for sedation
simvastatin, a drugs used to deal with excessive ldl cholesterol
hormonal contraceptive brokers (contraception medicines). Their effectiveness could also be
decreased while taking EFERAS and subsequently further contraception must be used
while taking this medication
sure painkillers or anti-inflammatory medicines (e.g. aspirin, ibuprofen, corticosteroids)
oral bisphosphonates, medicines used to deal with osteoporosis
anticoagulant medicines, medicines used to stop or deal with blood clots
antacids that include aluminum shouldn’t be taken on the identical time of day as EFERAS
repaglinide, a drugs used for kind 2 diabetes
medicines for epilepsy or sedation (e.g. phenytoin, phenobarbitone)
ritonavir, a drugs used to deal with HIV
rifampicin, a drugs used to deal with tuberculosis
paclitaxel, a drugs used within the remedy of most cancers
cholestyramine, a drugs used to take away bile acids
theophylline, a drugs used to deal with respiratory ailments reminiscent of bronchial asthma
busulfan, a drugs utilized in remedy previous to bone marrow transplant
Different medicines which might be processed within the physique like theophylline your physician ought to
learn about embody: clozapine, cyclobenzaprine, imipramine, haloperidol, fluvoxamine,
mexiletine, naproxen, olanzapine, riluzole, tacrine, tizanidine, zileuton and zolmitriptan.
Some medicines might intervene with EFERAS and have an effect on the way it works.
You might want completely different quantities of your medicines, or it’s possible you’ll must take completely different
Verify together with your physician or pharmacist in case you are unsure about what medicines, nutritional vitamins
or dietary supplements you take and if these have an effect on EFERAS.
How do I take advantage of EFERAS?
How a lot to take
The dose of EFERAS is said to your physique weight. Your physician will decide the
dose you must take.
The same old beginning dose is 14 mg per kilogram physique weight every day for sufferers receiving
common blood transfusions.
For sufferers NOT receiving common blood transfusions, the standard beginning dose is
7 mg per kilogram physique weight every day.
The next or decrease beginning dose could also be advisable by your physician based mostly in your particular person
Relying in your response, your physician might improve the dose to a most of 28 mg
per kilogram physique weight day by day should you obtain common blood transfusions or 14 mg
per kilogram physique weight in case you are NOT receiving common transfusions.
Observe the directions supplied and use EFERAS till your physician tells you to cease.
When to take EFERAS
EFERAS must be used at about the identical time every day. Taking it on the identical time
every day may have the most effective impact. It should additionally allow you to bear in mind when to take it.
Take your medication both on an empty abdomen or with a light-weight meal.
Don’t take this medication with a excessive fats meal. Meals can intervene with the absorption
of this medication.
If you happen to can not swallow the tablets entire, you possibly can crush them. Then sprinkle all of
it onto comfortable meals like yoghurt or apple sauce (apple puree). You must then eat it
all instantly. Don’t hold any to have later.
If you happen to overlook to make use of EFERAS
EFERAS must be used repeatedly on the identical time every day. If you happen to miss your dose at
the standard time, take it as quickly as you bear in mind, after which return to taking your medicines
as you’ll usually.
Whether it is virtually time on your subsequent dose, skip the dose you missed and take your subsequent
dose when you find yourself meant to.
Don’t take a double dose to make up for the dose you missed.
This will likely improve the possibility of you getting an undesirable aspect impact.
If you happen to use an excessive amount of EFERAS
If you happen to assume that you’ve used an excessive amount of EFERAS, it’s possible you’ll want pressing medical consideration.
You must instantly:
telephone the Poisons Info Centre
13 11 26), or
contact your physician, or
go to the Emergency Division at your nearest hospital.
You must do that even when there are not any indicators of discomfort or poisoning.
What ought to I do know whereas utilizing EFERAS?
Issues it’s best to do
Name your physician right away should you:
Are about to be began on any new medicines
Are going to have surgical procedure. Inform the surgeon or anesthetist that you’re taking this
medication. It might have an effect on different medicines used throughout surgical procedure.
Discover your urine output turns into considerably decreased. This may very well be an indication of a
downside together with your kidneys.
Turn out to be pregnant whereas taking this medication.
Are about to have any blood checks. It might intervene with the outcomes of some checks.
Remind any physician, dentist or pharmacist you go to that you’re utilizing EFERAS.
Preserve your whole physician’s appointments in order that your progress will be checked.
Your physician might do some checks reminiscent of blood, urine or magnetic resonance imaging (MIR)
to ensure the drugs is working and to stop undesirable negative effects.
Your eyesight and listening to could also be examined throughout remedy as a precautionary measure.
Issues you shouldn’t do
Don’t cease utilizing this medication or decrease the dosage with out checking together with your physician.
Don’t take EFERAS to deal with another complaints until your physician tells you to.
Don’t give your medication to anybody else, even when they’ve the identical situation as
Driving or utilizing machines
Watch out earlier than you drive or use any machines or instruments till you understand how EFERAS
EFERAS might trigger dizziness in some individuals. If you happen to expertise dizziness, don’t drive,
function equipment or do anything that may very well be harmful.
Taking care of your medication
Preserve your tablets within the pack till it’s time to take them. If you happen to take the tablets
out of the pack, they could not hold effectively.
Preserve your tablets in a cool dry place the place the temperature stays under 25°C.
Retailer it in a cool dry place away from moisture, warmth or daylight; for instance, do
not retailer it:
within the rest room or close to a sink, or
within the automobile or on window sills.
Preserve it the place younger kids can not attain it.
Eliminating any undesirable medication
If you happen to now not want to make use of this medication or it’s old-fashioned, take it to any pharmacy
for secure disposal.
Don’t use this medication after the expiry date.
Are there any negative effects?
All medicines can have negative effects. If you happen to do expertise any negative effects, most of
them are minor and short-term. Nevertheless, some negative effects might have medical consideration.
See the data under and, if you must, ask your physician or pharmacist should you
have any additional questions on negative effects.
Much less critical negative effects
Much less critical negative effects
What to do
Nausea, diarrhoea, vomiting, ache within the stomach, bloating, constipation or indigestion
Fever or signs of a chilly or flu
Cough or sore throat
Swelling of the arms or legs
Change within the color of your pores and skin
Sore muscular tissues or joints
Converse to your physician when you’ve got any of those much less critical negative effects and so they fear
Critical negative effects
Critical negative effects
What to do
Rash, pink pores and skin, blistering of the lips, eyes or mouth, pores and skin peeling, excessive fever, flu-like
A considerably decreased urine output (signal of kidney downside)
Vomiting with blood and/or black stools
Frequent heartburn or belly ache (ulcers), significantly after consuming or taking
Blurred, cloudy or partial lack of imaginative and prescient
Listening to disturbances
Sudden again ache or ache on the proper aspect of the stomach (indicators of gallstones)
Extreme higher abdomen ache (pancreatitis)
Problem in respiration or swallowing
Swelling of the face, lips, tongue or throat
Extreme itching of the pores and skin with a pink rash or raised bumps
Drowsiness, higher proper belly ache, yellowing of the pores and skin or eyes and darkish urine
Inform your physician as quickly as doable should you discover any of the next. These are
Name your physician right away, or go straight to the Emergency Division at your
Inform your physician or pharmacist should you discover anything which may be making you
really feel unwell.
Different negative effects not listed right here might happen in some individuals.
Reporting negative effects
report negative effects to the Therapeutic Items Administration on-line at www.tga.gov.au/reporting-problems . By reporting negative effects, you possibly can assist present extra data on the security of
All the time ensure you communicate to your physician or pharmacist earlier than you resolve to cease
taking any of your medicines.
This medication is barely out there with a physician’s prescription.
What EFERAS comprises
(most important ingredient)
90 mg, 180 mg or 360 mg deferasirox
Colloidal anhydrous silica
Opadry Full Movie Coating System 03F505168 Blue (Proprietary Ingredient: 123028)
Don’t take this medication in case you are allergic to any of those elements.
What EFERAS seems like
EFERAS tablets can be found in three completely different strengths.
EFERAS 90 mg: blue, movie coated capsule formed biconvex pill debossed with “M” on
one aspect and “DF” on the opposite (AUST R 331686)
EFERAS 180 mg: blue, movie coated capsule formed biconvex pill debossed with “M”
on one aspect and “DF1” on the opposite (AUST R 331685)
EFERAS 360 mg: blue, movie coated capsule formed biconvex pill debossed with “M”
on one aspect and “DF2” on the opposite (AUST R 331687)
The tablets can be found in blister packs of 30.
Who distributes EFERAS
Alphapharm Pty Ltd
Degree 1, 30 The Bond
30-34 Hickson Highway
Millers Level NSW 2000
This leaflet was ready in April 2021.